V001 / JSI / T534

Slika

B3 - Department of Biotechnology and F4 - Department of Surface Technology of the Jožef Stefan Institute published an interdisciplinary study in the journal Biomaterials Science entitled Cold atmospheric plasma induces stress granule formation via eIF2α – dependent pathway. The paper reveals the complex mechanism of formation of stress granules in neurons after their exposure to atmospheric plasma, which is a known trigger of oxidative stress. The cellular medium, which is exposed to plasma and consequently enriched with various radicals, triggers the primary response of cells that manifests in the formation of stress granules in the cytoplasm. In plasma-treated cells, various signaling pathways are activated, one of which also involves phosphorylation of the eIF2α protein. Our study was the first to characterize plasma-induced stress granule formation, which increases the regenerative and metabolic capacity of cells and has the potential for use in tissue healing in regenerative medicine.