The researchers from Department F6 have achieved an ultrafast differentiation by genomic GC content of the bacterial DNA at a molecular level using surface-enhanced Raman spectroscopy (SERS) and fine-tuned plasmonic gold nanocrystals. Their atmospheric-pressure plasma-designed truncated plasmonic particulates revealed truly exceptional optical response within nanometric gaps between gold dimers/chains, from where the molecular fingerprints of bacterial DNA fragments gained the strongest Raman signal enhancement. It allowed not only to collect vibrational data from different DNA samples but also, for the first time, to distinguish reliably between bacterial species due to intrinsically different compositions of nucleobases adenine, guanine, cytosine, and thymine within the biological macromolecule. The realized approach was successfully validated by cutting-edge third-generation sequencing nanopore technology and published in NanoLetters.